Duopharma was established as a pharmaceutical trading company in 1979. Its business then was in the import and marketing of pharmaceutical products. It started manufacturing tablets, capsules and other oral preparations in 1986.

In 1995, Duopharma shifted to its present premises - a 85,000 sq.ft factory situated on a 130,000 sq.ft. land. It started production of heamodialysis liquid in January 1996 and a month later, the production of small volume injectables including eye drops, antibiotic powder and dental cartridges. In July that same year, it started volume infusion production